Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme

Angiotensin-converting enzyme (ACE) is best known for the catalytic conversion of angiotensin I to angiotensin II. However, the use of gene-targeting techniques has led to mouse models highlighting many other biochemical properties and actions of this enzyme. This review discusses recent studies exa...

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Bibliographic Details
Published inJournal of molecular medicine (Berlin, Germany) Vol. 91; no. 10; pp. 1143 - 1154
Main Authors Gonzalez-Villalobos, Romer A., Shen, Xiao Z., Bernstein, Ellen A., Janjulia, Tea, Taylor, Brian, Giani, Jorge F., Blackwell, Wendell-Lamar B., Shah, Kandarp H., Shi, Peng D., Fuchs, Sebastien, Bernstein, Kenneth E.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2013
Springer Nature B.V
Subjects
Active sites
Angiotensin
Angiotensin I
Angiotensin II
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Blood pressure
Cytokines - genetics
Cytokines - metabolism
Endothelial Cells - metabolism
Gene Expression
Histocompatibility Antigens Class I - chemistry
Histocompatibility Antigens Class I - immunology
Human Genetics
Humans
Hypertension - etiology
Immunity - physiology
Immunologic Memory
Internal Medicine
Kidney - metabolism
Kidney - physiology
Mice
Mice, Knockout
Molecular Medicine
Peptides
Peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - chemistry
Peptidyl-Dipeptidase A - physiology
Phenotype
Protein Interaction Domains and Motifs
Review
MHC class I
Blood pressure
Ac-SDKP
Angiotensin II
Kidney function
Antigen processing
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Summary:Angiotensin-converting enzyme (ACE) is best known for the catalytic conversion of angiotensin I to angiotensin II. However, the use of gene-targeting techniques has led to mouse models highlighting many other biochemical properties and actions of this enzyme. This review discusses recent studies examining the functional significance of ACE tissue-specific expression and the presence in ACE of two independent catalytic sites with distinct substrates and biological effects. It is these features which explain why ACE makes important contributions to many different physiological processes including renal development, blood pressure control, inflammation, and immunity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-013-1051-z