Estrogen receptors and lesion-induced response of striatal dopamine receptors

• Published in: Neuroscience Vol. 236; pp. 99 - 109
• Main Authors: Al Sweidi, S, Morissette, M, Rouillard, C, Di Paolo, T
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 16.04.2013; Elsevier
• Subjects: 17β-estradiol; Akt; Animals; Autoradiography; Biological and medical sciences; Blotting, Western; Corpus Striatum - metabolism; Corpus Striatum - pathology; ERK; estrogen receptor; Fundamental and applied biological sciences. Psychology; GSK3; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP; MPTP Poisoning - metabolism; Neurology; Receptors, Dopamine - metabolism; Receptors, Estrogen - metabolism; Signal Transduction - physiology; Vertebrates: nervous system and sense organs; 17β-E 2; extracellular signal-regulated kinase; D1 dopamine receptor; estrogen receptor alpha; phosphate-buffered saline; EEDQ; mitogen-activated protein kinase; BSA; estrogen receptor beta; GSK3; sodium dodecyl sulfate; 17β-estradiol; estrogen receptor knock out; SN; N-ehtoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; WT; protein kinase B; D2 dopamine receptor; PBS; substantia nigra; SDS; ERβ; ERα; estrogen receptor; Akt; MAPK; D1; D2; ERKO; PD; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; wild type; MPTP; DA; dopamine; bovine serum albumin; glycogen synthase kinase 3; Parkinson’s disease; ERK; 17β-E2; Estrogen receptor; Extracellular signal-regulated protein kinase; Enzyme; Dopamine receptor; Glycogen synthase kinase-3; Central nervous system; 17β-Estradiol; Basal ganglion; Corpus striatum; Encephalon; Toxin; Neurotoxin; Lesion
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.12.058

Highlights ► MPTP increased striatal D2 receptor levels in ERKOβ but not in ERKOα or WT mice. ► Striatal DA levels correlated with D1 and D2 receptors with genotype specificity. ► 17β-E2 increased D1 in MPTP ERKO mice and D2 receptors in WT and ERKOβ mice. ► MPTP did not affect striatal pAkt, pGSK3β, pERK1 and pERK2 in WT and ERKOα mice. ► In intact ERKOβ mice, these levels were higher and increased with MPTP lesioning.