Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni

• Published in: The New England journal of medicine Vol. 350; no. 3; pp. 239 - 248
• Main Authors: Lecuit, Marc, Abachin, Eric, Martin, Antoine, Poyart, Claire, Pochart, Philippe, Suarez, Felipe, Bengoufa, Djaouida, Feuillard, Jean, Lavergne, Anne, Gordon, Jeffrey I, Berche, Patrick, Guillevin, Loïc, Lortholary, Olivier
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 15.01.2004
• Subjects: Anti-Bacterial Agents; Anti-Ulcer Agents; Anti-Ulcer Agents - therapeutic use; Bacterial infections; Bacteriology; Biological and medical sciences; Campylobacter Infections; Campylobacter jejuni; Campylobacter jejuni - genetics; Campylobacter jejuni - isolation & purification; DNA, Bacterial; DNA, Bacterial - analysis; Drug Therapy, Combination; Drug Therapy, Combination - therapeutic use; Female; Genes, Immunoglobulin; Hematologic and hematopoietic diseases; Human health and pathology; Humans; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin Fragments; Immunoglobulin Fragments - analysis; Immunoglobulin Fragments - genetics; Immunohistochemistry; Immunoproliferative Small Intestinal Disease; Immunoproliferative Small Intestinal Disease - drug therapy; Immunoproliferative Small Intestinal Disease - microbiology; Immunoproliferative Small Intestinal Disease - pathology; In Situ Hybridization, Fluorescence; Infections; Infectious diseases; Intestine, Small; Intestine, Small - immunology; Intestine, Small - microbiology; Intestine, Small - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Life Sciences; Lymphocytes; Lymphoma; Medical sciences; Microbiology and Parasitology; Middle Aged; Omeprazole; Omeprazole - therapeutic use; Plasma; Polymerase Chain Reaction; Sequence Analysis, DNA; Middle East; Human; Campylobacteraceae; Host agent relation; Malignant hemopathy; Non Hodgkin lymphoma; Small intestine; Campylobacter jejuni; Infection; Campylobacter infection; Association; MALT lymphoma; Etiology; Lymphoproliferative syndrome; Bacteriosis; Digestive diseases; Bacteria; Intestinal disease
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa031887

Immunoproliferative small intestinal disease is a type of gastrointestinal lymphoma that responds to antibiotics and may be triggered by a bacterial pathogen. The authors identified Campylobacter jejuni in gastrointestinal-tissue samples from a patient with immunoproliferative small intestinal disease. The pathogen was no longer detectable eight days after treatment with antibiotics. Campylobacter was also found in archival tissue samples from four of six additional patients with immunoproliferative small intestinal disease. Evidence that C. jejuni may trigger an immunoproliferative disease. Immunoproliferative small intestinal disease, also known as alpha chain disease, is a mucosa-associated lymphoid-tissue (MALT) lymphoma characterized by infiltration of the bowel wall with a plasma-cell population that secretes a monotypic, truncated immunoglobulin α heavy chain lacking an associated light chain. 1 – 3 Lymphoid infiltration leads to malabsorption and protein-losing enteropathy. The disease can cause a spectrum of histopathological changes, ranging from seemingly benign lymphoid infiltration to malignant diffuse large-B-cell lymphoma. Since its initial description, 1 immunoproliferative small intestinal disease has largely been reported in the Mediterranean basin, the Middle East, the Far East, and Africa. In the Middle East, the most . . .