Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni
Immunoproliferative small intestinal disease is a type of gastrointestinal lymphoma that responds to antibiotics and may be triggered by a bacterial pathogen. The authors identified Campylobacter jejuni in gastrointestinal-tissue samples from a patient with immunoproliferative small intestinal disea...
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Published in | The New England journal of medicine Vol. 350; no. 3; pp. 239 - 248 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Boston, MA
Massachusetts Medical Society
15.01.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Immunoproliferative small intestinal disease is a type of gastrointestinal lymphoma that responds to antibiotics and may be triggered by a bacterial pathogen. The authors identified
Campylobacter jejuni
in gastrointestinal-tissue samples from a patient with immunoproliferative small intestinal disease. The pathogen was no longer detectable eight days after treatment with antibiotics. Campylobacter was also found in archival tissue samples from four of six additional patients with immunoproliferative small intestinal disease.
Evidence that
C. jejuni
may trigger an immunoproliferative disease.
Immunoproliferative small intestinal disease, also known as alpha chain disease, is a mucosa-associated lymphoid-tissue (MALT) lymphoma characterized by infiltration of the bowel wall with a plasma-cell population that secretes a monotypic, truncated immunoglobulin α heavy chain lacking an associated light chain.
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Lymphoid infiltration leads to malabsorption and protein-losing enteropathy. The disease can cause a spectrum of histopathological changes, ranging from seemingly benign lymphoid infiltration to malignant diffuse large-B-cell lymphoma.
Since its initial description,
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immunoproliferative small intestinal disease has largely been reported in the Mediterranean basin, the Middle East, the Far East, and Africa. In the Middle East, the most . . . |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJMoa031887 |