Recent advances in screening active components from natural products based on bioaffinity techniques
Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (20...
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Published in | Acta pharmaceutica Sinica. B Vol. 10; no. 10; pp. 1800 - 1813 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.10.2020
Elsevier |
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Abstract | Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents.
This review summarizes the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques. [Display omitted] |
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AbstractList | Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents.
This review summarizes the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques.
Image 1 Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents. Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents. This review summarizes the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques. [Display omitted] |
Author | Bao, Tao Sun, Meng Wang, Sicen Xie, Xiaoyu Wei, Fen Hou, Xiaofang |
Author_xml | – sequence: 1 givenname: Xiaofang surname: Hou fullname: Hou, Xiaofang organization: School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China – sequence: 2 givenname: Meng surname: Sun fullname: Sun, Meng organization: College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China – sequence: 3 givenname: Tao surname: Bao fullname: Bao, Tao organization: School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China – sequence: 4 givenname: Xiaoyu surname: Xie fullname: Xie, Xiaoyu organization: School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China – sequence: 5 givenname: Fen surname: Wei fullname: Wei, Fen organization: School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China – sequence: 6 givenname: Sicen surname: Wang fullname: Wang, Sicen email: wangsc@mail.xjtu.edu.cn organization: School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China |
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Copyright | 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences |
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Title | Recent advances in screening active components from natural products based on bioaffinity techniques |
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