Recent advances in screening active components from natural products based on bioaffinity techniques

Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (20...

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Bibliographic Details
Published inActa pharmaceutica Sinica. B Vol. 10; no. 10; pp. 1800 - 1813
Main Authors Hou, Xiaofang, Sun, Meng, Bao, Tao, Xie, Xiaoyu, Wei, Fen, Wang, Sicen
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.10.2020
Elsevier
Subjects
Active components
Bioaffinity techniques
Natural products
Review
Screening
Active components
ASMS
HTS
MPTS
CNT
APTES
FP
EGFR
MNP
UF
Fe3O4–NH2
TCMs
AAs
SPR
CMC
CMSP
HUVEC
TYR-MNPs
ABCA1
ChE
ACE
Topo I
Bioaffinity techniques
MS
STAT3
MAO-B
PMG
TYR
XOD
CMMCNTs
RGD
Screening
IMER
PD
Natural products
HCS
α1A-AR
MSPE
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Summary:Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents. This review summarizes the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques. [Display omitted]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2020.04.016