Associations of hypertension and complications in non-insulin-dependent diabetes mellitus

• Published in: American journal of hypertension Vol. 10; no. 2; pp. 152 - 161
• Main Authors: Mehler, Philip S., Jeffers, Barrett W., Estacio, Raymond, Schrier, Robert W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1997; Oxford University Press; Elsevier Science
• Subjects: Aged; Associated diseases and complications; Biological and medical sciences; Blood Pressure; cardiovascular disease; Cardiovascular Diseases - classification; Cross-Cultural Comparison; Diabetes Mellitus - prevention & control; Diabetes Mellitus, Type 2 - etiology; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; hypertension; Hypertension - etiology; Hypertension - physiopathology; Male; Medical sciences; Middle Aged; nephropathy; neuropathy; Non-insulin-dependent diabetes mellitus; retinopathy; cardiovascular disease; nephropathy; neuropathy; Non-insulin-dependent diabetes mellitus; retinopathy; hypertension; Endocrinopathy; Kidney disease; Human; Hypertension; Nervous system diseases; Urinary system disease; Retinopathy; Diabetes mellitus; Cardiovascular disease; Peripheral neuropathy; Non insulin dependent diabetes; Eye disease; Nephropathy; Complication; Peripheral nerve disease
• ISSN: 0895-7061; 1879-1905; 1941-7225
• DOI: 10.1016/S0895-7061(96)00344-5

Hypertension is a common comorbidity with non-insulin-dependent diabetes mellitus (NIDDM). Data are somewhat inconsistent as to whether hypertension exacerbates diabetic complications in this population. Therefore, we examined the relationship between hypertension and vascular complications of NIDDM in the 950 patients enrolled in the prospective and randomized Appropriate Blood Pressure Control in Diabetes (ABCD) study. We found both systolic and diastolic hypertension to be associated with diabetic nephropathy ( P < .001) as well as with its macrovascular complications ( P < .05). Our present results also demonstrated that there was a significant relationship between hypertension and peripheral vascular disease ( P < .05), and left ventricular hypertrophy ( P < .001). There was, however, no apparent relationship between hypertension and diabetic neuropathy. Thus, arterial pressure may be a major determinant of complications in NIDDM.