The role of programmed cell death in diabetic foot ulcers

Diabetic foot ulcer, is a chronic complication afflicting individuals with diabetes, continue to increase worldwide, immensely burdening society. Programmed cell death, which includes apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis, has been increasingly implicated in the pathogenesis...

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Bibliographic Details
Published inInternational wound journal Vol. 21; no. 2
Main Authors Li, Juncheng, Jiang, Chengli, Xia, Jian
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.2024
John Wiley & Sons, Inc
Subjects
Adapter proteins
Apoptosis
Cell death
Cytochrome
Diabetes
diabetic foot ulcers
Fibroblasts
Foot diseases
Growth factors
Hyperglycemia
Ingredients
Leg ulcers
Metabolism
MicroRNAs
natural active ingredients
noncoding RNAs
Organisms
Pathogenesis
programmed cell death
protein
Review
Roles
Stem cells
Tumor necrosis factor-TNF
Wound healing
natural active ingredients
diabetic foot ulcers
noncoding RNAs
programmed cell death
protein
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Summary:Diabetic foot ulcer, is a chronic complication afflicting individuals with diabetes, continue to increase worldwide, immensely burdening society. Programmed cell death, which includes apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis, has been increasingly implicated in the pathogenesis of diabetic foot ulcer. This review is based on an exhaustive examination of the literature on ‘programmed cell death’ and ‘diabetic foot ulcers’ via PubMed. The findings revealed that natural bioactive compounds, noncoding RNAs and certain proteins play crucial roles in the healing of diabetic foot ulcers through various forms of programmed cell death, including apoptosis, autophagy, ferroptosis and pyroptosis.
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ISSN:1742-4801
1742-481X
1742-481X
DOI:10.1111/iwj.14399