Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma

: Therapeutic approaches for non‐Hodgkin's lymphoma (NHL) are currently based on the International Prognostic Index (IPI). Research on biological prognostic factors has been actively pursued in recent years, with serum vascular endothelial growth factor (VEGF) and interleukin‐6 (IL‐6) being ide...

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Published inEuropean journal of haematology Vol. 68; no. 2; pp. 91 - 100
Main Authors Niitsu, Nozomi, Okamoto, Masataka, Nakamine, Hirokazu, Yoshino, Tadashi, Tamaru, Jun-ichi, Nakamura, Shigeo, Higashihara, Masaaki, Hirano, Masami
Format Journal Article
LanguageEnglish
Published Oxford, UK Munksgaard International Publishers 01.02.2002
Blackwell
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Summary:: Therapeutic approaches for non‐Hodgkin's lymphoma (NHL) are currently based on the International Prognostic Index (IPI). Research on biological prognostic factors has been actively pursued in recent years, with serum vascular endothelial growth factor (VEGF) and interleukin‐6 (IL‐6) being identified as prognostic factors for NHL. Here, we determined that serum VEGF and IL‐6 levels are independent prognostic factors for aggressive lymphoma. Compared with normal controls, serum VEGF and IL‐6 levels were significantly higher in patients with aggressive lymphoma or adult T‐cell leukemia/lymphoma. Furthermore, overall and disease‐free survival rates for patients with high levels of VEGF or IL‐6 were significantly poorer than for patients with low levels. In addition, the prognosis for patients with high levels of both serum VEGF and IL‐6 was significantly poorer than that for patients with high levels of either VEGF or IL‐6 or with low levels of both VEGF and IL‐6. Multivariate analyses of a variety of prognostic factors, including the five IPI factors, revealed that serum VEGF and IL‐6 were both independent prognostic factors for overall survival of aggressive lymphoma. Therefore, a combination of VEGF and IL‐6 represents a useful prognostic factor for aggressive lymphoma.
Bibliography:istex:3931709853831AAC9F5DF411A066E541826153FC
ark:/67375/WNG-3QTPSZV4-D
ArticleID:EJH609
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0902-4441
1600-0609
DOI:10.1034/j.1600-0609.2002.01609.x