Maggot debridement therapy stimulates wound healing by altering macrophage activation

The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC)....

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Published inInternational wound journal Vol. 21; no. 3; pp. e14477 - n/a
Main Authors Sun, Xin‐Juan, Chen, Jin‐An, Li, Gai, Wang, Lei, Wang, Tian‐Yuan, Wang, Ai‐Ping
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2024
John Wiley & Sons, Inc
Subjects
Aged
Angiogenesis
Animals
Biopsy
Cytokines
Debridement
Debridement - methods
Diabetes
Diabetic Foot - therapy
diabetic foot ulcer
Female
Foot diseases
Genotype & phenotype
Humans
Ischemia
Laboratories
Larva
Leg ulcers
Macrophage Activation
macrophages
Macrophages - immunology
Maggot Debridement Therapy
Male
Middle Aged
Original
Proteins
R&D
Research & development
Tumor necrosis factor-TNF
Wound healing
Wound Healing - physiology
United States > US
Texas
macrophages
wound healing
diabetic foot ulcer
maggot debridement therapy
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Abstract The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC). In addition, markers associated with macrophage activation were discovered using immunoblotting and real‐time polymerase chain reaction (PCR). During the process of diabetic wound healing following MDT, the presence and over‐expression of M2 macrophages were observed, while the under‐expression of M1 macrophages was noted. In addition, the activation markers of macrophages exhibited a correlation with the indicated Th1/Th2 cytokines. MDT interventions have the potential to modulate macrophage activity, thereby aiding in the healing of diabetic foot wounds.
AbstractList The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC). In addition, markers associated with macrophage activation were discovered using immunoblotting and real‐time polymerase chain reaction (PCR). During the process of diabetic wound healing following MDT, the presence and over‐expression of M2 macrophages were observed, while the under‐expression of M1 macrophages was noted. In addition, the activation markers of macrophages exhibited a correlation with the indicated Th1/Th2 cytokines. MDT interventions have the potential to modulate macrophage activity, thereby aiding in the healing of diabetic foot wounds.
The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC). In addition, markers associated with macrophage activation were discovered using immunoblotting and real-time polymerase chain reaction (PCR). During the process of diabetic wound healing following MDT, the presence and over-expression of M2 macrophages were observed, while the under-expression of M1 macrophages was noted. In addition, the activation markers of macrophages exhibited a correlation with the indicated Th1/Th2 cytokines. MDT interventions have the potential to modulate macrophage activity, thereby aiding in the healing of diabetic foot wounds.The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC). In addition, markers associated with macrophage activation were discovered using immunoblotting and real-time polymerase chain reaction (PCR). During the process of diabetic wound healing following MDT, the presence and over-expression of M2 macrophages were observed, while the under-expression of M1 macrophages was noted. In addition, the activation markers of macrophages exhibited a correlation with the indicated Th1/Th2 cytokines. MDT interventions have the potential to modulate macrophage activity, thereby aiding in the healing of diabetic foot wounds.
Author Wang, Lei
Wang, Ai‐Ping
Wang, Tian‐Yuan
Chen, Jin‐An
Li, Gai
Sun, Xin‐Juan
AuthorAffiliation 1 Diabetic Foot Center Junxie Hospital Nanjing China
AuthorAffiliation_xml – name: 1 Diabetic Foot Center Junxie Hospital Nanjing China
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  fullname: Sun, Xin‐Juan
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  givenname: Jin‐An
  surname: Chen
  fullname: Chen, Jin‐An
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  surname: Li
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  organization: Junxie Hospital
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CitedBy_id crossref_primary_10_1016_j_ijbiomac_2024_137789
Cites_doi 10.1016/S0065‐2776(05)87003‐8
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Issue 3
Keywords macrophages
wound healing
diabetic foot ulcer
maggot debridement therapy
Language English
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2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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Notes Xin‐Juan Sun and Jin‐An Chen authors contributed equally to this study.
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  doi: 10.1046/j.1365-4362.2002.01354.x
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Snippet The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers...
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SourceType Open Access Repository
Aggregation Database
Index Database
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StartPage e14477
SubjectTerms Aged
Angiogenesis
Animals
Biopsy
Cytokines
Debridement
Debridement - methods
Diabetes
Diabetic Foot - therapy
diabetic foot ulcer
Female
Foot diseases
Genotype & phenotype
Humans
Ischemia
Laboratories
Larva
Leg ulcers
Macrophage Activation
macrophages
Macrophages - immunology
Maggot Debridement Therapy
Male
Middle Aged
Original
Proteins
R&D
Research & development
Tumor necrosis factor-TNF
Wound healing
Wound Healing - physiology
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Title Maggot debridement therapy stimulates wound healing by altering macrophage activation
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fiwj.14477
https://www.ncbi.nlm.nih.gov/pubmed/37944931
https://www.proquest.com/docview/3090609783
https://www.proquest.com/docview/2889245348
https://pubmed.ncbi.nlm.nih.gov/PMC10898370
Volume 21
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