Maggot debridement therapy stimulates wound healing by altering macrophage activation

The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC)....

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Bibliographic Details
Published inInternational wound journal Vol. 21; no. 3; pp. e14477 - n/a
Main Authors Sun, Xin‐Juan, Chen, Jin‐An, Li, Gai, Wang, Lei, Wang, Tian‐Yuan, Wang, Ai‐Ping
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2024
John Wiley & Sons, Inc
Subjects
Aged
Angiogenesis
Animals
Biopsy
Cytokines
Debridement
Debridement - methods
Diabetes
Diabetic Foot - therapy
diabetic foot ulcer
Female
Foot diseases
Genotype & phenotype
Humans
Ischemia
Laboratories
Larva
Leg ulcers
Macrophage Activation
macrophages
Macrophages - immunology
Maggot Debridement Therapy
Male
Middle Aged
Original
Proteins
R&D
Research & development
Tumor necrosis factor-TNF
Wound healing
Wound Healing - physiology
United States > US
Texas
macrophages
wound healing
diabetic foot ulcer
maggot debridement therapy
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Summary:The purpose of this study is to determine the impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU). The activation phenotype of macrophages during wound healing following MDT was evaluated using double staining immunohistochemistry (IHC). In addition, markers associated with macrophage activation were discovered using immunoblotting and real‐time polymerase chain reaction (PCR). During the process of diabetic wound healing following MDT, the presence and over‐expression of M2 macrophages were observed, while the under‐expression of M1 macrophages was noted. In addition, the activation markers of macrophages exhibited a correlation with the indicated Th1/Th2 cytokines. MDT interventions have the potential to modulate macrophage activity, thereby aiding in the healing of diabetic foot wounds.
Bibliography:Xin‐Juan Sun and Jin‐An Chen authors contributed equally to this study.
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ISSN:1742-4801
1742-481X
1742-481X
DOI:10.1111/iwj.14477