Neuroendocrine features in poorly differentiated and undifferentiated carcinomas of the cervix

Neuroendocrine or argyrophil cell carinoma of the cervix has recently been accepted as a distinct clinical‐pathological entity. The histologic pattern of these carcinomas is usually poorly differentiated or undifferentiated. Twenty patients with a histologic diagnosis of small cell carcinoma, undiff...

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Published inCancer Vol. 60; no. 9; pp. 2325 - 2330
Main Authors Barrett, Rolland J., Davos, Irene, Leuchter, Ronald S., Lagasse, Leo D.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.11.1987
Wiley-Liss
Subjects
Adenocarcinoma - pathology
Adult
Aged
Biological and medical sciences
Carcinoma, Small Cell - pathology
Carcinoma, Squamous Cell - pathology
Cytoplasmic Granules - pathology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunoenzyme Techniques
Medical sciences
Middle Aged
Neurosecretory Systems - pathology
Tumors
Uterine Cervical Neoplasms - analysis
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - ultrastructure
Human
Pathology
Neurosecretory cell
Tumor
Uterine cervix
Cell differentiation
Woman
Female genital diseases
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Summary:Neuroendocrine or argyrophil cell carinoma of the cervix has recently been accepted as a distinct clinical‐pathological entity. The histologic pattern of these carcinomas is usually poorly differentiated or undifferentiated. Twenty patients with a histologic diagnosis of small cell carcinoma, undifferentiated carcinoma, poorly differentiated adenocarcinoma, or poorly differentiated, adenosquamous carcinoma of the cervix were evaluated for neuroendocrine features. The results of studies to detect neurosecretory granules were positive in seven of the 20 cases. Not only small cell carcinomas, but also tumors classified as undifferentiated carcinoma and poorly differentiated, adenosquamous carcinoma contained cytoplasmic granules consistent with neuroendocrine carcinoma of the cervix. The prognosis for survival appears poorer for patients having tumors with neurosecretory granules after controlling for stage and histologic grade of the neoplasm.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19871101)60:9<2325::AID-CNCR2820600935>3.0.CO;2-G