Guided tissue regeneration for the treatment of intraosseous defects using a biabsorbable membrane A controlled clinical study

• Published in: Journal of clinical periodontology Vol. 25; no. 7; pp. 585 - 595
• Main Authors: Mayfield, L., Söderholm, G., Hallström, H., Kullendorff, B., Edwardsson, S., Bratthall, G., Brägger, U., Attström, R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.1998
• Subjects: Absorption; Alveolar Bone Loss - diagnostic imaging; Alveolar Bone Loss - microbiology; Alveolar Bone Loss - pathology; Alveolar Bone Loss - surgery; Alveolar Process - diagnostic imaging; Alveolar Process - pathology; bioabsorbable membrane; Biocompatible Materials; Citrates; Colony Count, Microbial; Dentistry; Evaluation Studies as Topic; Follow-Up Studies; guided tissue regeneration; Guided Tissue Regeneration, Periodontal - instrumentation; Guided Tissue Regeneration, Periodontal - methods; Humans; intraosseous defect; Membranes, Artificial; Middle Aged; Periodontal Attachment Loss - microbiology; Periodontal Attachment Loss - pathology; Periodontal Attachment Loss - surgery; Periodontal Pocket - microbiology; Periodontal Pocket - pathology; Periodontal Pocket - surgery; periodontal therapy; Polyesters; Porphyromonas gingivalis - growth & development; Prevotella intermedia - growth & development; Radiography; Single-Blind Method; smoking; Smoking - adverse effects; Surgical Flaps; Treatment Outcome; Wound Healing
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1111/j.1600-051X.1998.tb02492.x

. The aim of this controlled, clinical study was to evaluate guided tissue regeneration using a bioabsorbable membrane in periodontal intraosscous defects. Forty patients, each contributing one defect ≥4 mm in depth participated. The control group (18 individuals) received conventional flap therapy, while the test group (22 individuals) was treated using the bioabsorbable membrane, Guidor®. Clinical assessments were made by one examiner, blinded with respect to treatment group, at baseline. 6 and 12 months following surgery. Baseline probing pocket depths of 7.7±1.4 mm in the membrane group and 7.6±1.9 mm in the control group were measured. Twelve month results showed a significant clinical attachment level gain in both control (1.1 ± 1.8 mm), and membrane group (1.3±2.1 mm). Probing pocket depth reduction of 2. 6±1.9 mm and 2.7±1.9 mm was observed in the respective groups. Bone sounding showed a non‐significant gain of 0. 4±1.8 mm and 0.6±1.4 mm at membrane and control sites, respectively. Radiographic evaluation confirmed these results. There were no significant differences found between treatment groups for any of the tested variables. Smoking had a negative effect on healing in both groups. In conclusion, clinical and radiographic results indicate that guided tissue regeneration using a bioabsorbable membrane at intraosseous defects did not predictably achieve greater clinical attachment level gain nor bone gain when compared to conventional flap therapy.