Interaction of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Signalling: Relevance to Schizophrenia and Depression

• Published in: Journal of neuroendocrinology Vol. 24; no. 12; pp. 1553 - 1561
• Main Author: Hill, R. A.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.12.2012; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult and adolescent clinical studies; Animals; Biological and medical sciences; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Brain-Derived Neurotrophic Factor - physiology; Depression; Depression - blood; Depression - genetics; Depression - metabolism; development; Epistasis, Genetic - physiology; Fundamental and applied biological sciences. Psychology; Gonadal Steroid Hormones - blood; Gonadal Steroid Hormones - metabolism; Gonadal Steroid Hormones - pharmacology; Gonadal Steroid Hormones - physiology; Humans; Literature reviews; Medical sciences; Mental disorders; Models, Biological; Mood disorders; Neurodevelopmental disorders; Neurotrophic factors; neurotrophins; oestrogen; Pruning; psychiatric illness; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Receptor, trkB - genetics; Receptor, trkB - metabolism; Receptor, trkB - physiology; Schizophrenia; Schizophrenia - blood; Schizophrenia - genetics; Schizophrenia - metabolism; Sex; Signal Transduction - genetics; Signal Transduction - physiology; Steroid hormones; testosterone; Vertebrates: endocrinology; Mood disorder; Neurotrophin; Tyrosine; oestrogen; Androgen; Interaction; Estrogen; Schizophrenia; Depression; Ovarian hormone; Psychosis; Testosterone; psychiatric illness; Aminoacid; Development; Mental disorder; Testicular hormone; Brain derived neurotrophic factor; Sex steroid hormone; neurotrophins
• ISSN: 0953-8194; 1365-2826
• DOI: 10.1111/j.1365-2826.2012.02365.x

Sex steroid hormones and neurotrophic factors are involved in pruning and shaping the developing brain and have been implicated in the pathogenesis of neurodevelopmental disorders. Sex steroid hormones are also involved in the regulation of brain‐derived neurotrophic factor expression. A review of the literature is provided on the relationship between brain‐derived neurotrophic factor and sex steroid hormones, as well as the mechanisms behind this interaction, in the context of how this relationship may be involved in the development of neurodevelopmental psychiatric illnesses, such as schizophrenia and depression.