Changes in systolic time intervals—a non‐invasive marker for the haemodynamic effects of sumatriptan

• Published in: British journal of clinical pharmacology Vol. 48; no. 3; pp. 331 - 335
• Main Authors: Hood, Stuart, Birnie, David, Murray, Lilian S., MacIntyre, Paul D., Hillis, W. Stewart
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.1999; Blackwell Science; Blackwell Science Inc
• Subjects: 5‐hydroxytryptamine; Biological and medical sciences; Blood Pressure - drug effects; Cardiovascular system; Electrocardiography - drug effects; Electrocardiography. Vectocardiography; Electrodiagnosis. Electric activity recording; Female; Heart Rate - drug effects; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Original; Pharmacology. Drug treatments; Serotonin Receptor Agonists - pharmacology; sumatriptan; Sumatriptan - pharmacology; Systole - drug effects; systolic time intervals; Time Factors; vasoconstriction; Vasodilator agents. Cerebral vasodilators; Agonist; Intravenous administration; Sumatriptan; Biological marker; Cardiovascular disease; 5-HT1 Serotonine receptor; Vascular disease; Electrodiagnosis; Pain; Electrocardiography; Subcutaneous administration; Cerebrovascular disease; Human; Nervous system diseases; Antimigrainous agent; Migraine; Single dose; Controlled therapeutic trial; Sympathomimetic; Cerebral disorder; Chemotherapy; Systolic time interval; Treatment; Central nervous system disease; Non invasive method; Hemodynamics; Comparative study
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1046/j.1365-2125.1999.00121.x

Aims This study assessed the use of systolic time intervals (STI) as a potential non‐invasive marker of the haemodynamic effects of sumatriptan, a 5HT1 receptor agonist. Methods Twenty‐six patients undergoing diagnostic cardiac catheterization participated. STIs were derived from haemodynamic pressure tracings at baseline, following placebo injection and following either subcutaneous (n=18) or intravenous injection (n=8) of sumatriptan. Results Sumatriptan (i.v. or s.c.) was associated with significant increases in mean arterial pressure (95% C.I. 9,14mmHg, P=0.0001), total electromechanical systole (95% C.I.8,36ms, P<0.0001), pre‐ejection period (95%C.I. 8,21ms, P=0.0001) and left ventricular ejection time (95% C.I. 2,12ms, P=0.004). Conclusion STI responses were consistent with sumatriptan‐induced changes in afterload. In summary, the measurement of STIs is a potential non‐invasive method of investigating the influence of serotonergic compounds on the cardiovascular system.