ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease

• Published in: Neuroscience letters Vol. 177; no. 1; pp. 100 - 102
• Main Authors: Sorbi, Sandro, Nacmias, Benedetta, Forleo, Paolo, Latorraca, Stefania, Gobbini, Ida, Bracco, Laura, Piacentini, Silvia, Amaducci, Luigi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.08.1994; Elsevier
• Subjects: Age of Onset; Aged; Aged, 80 and over; Alleles; Alzheimer Disease - epidemiology; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E; Apolipoproteins E - genetics; Base Sequence; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Gene Frequency; Genes; Genetic Predisposition to Disease; Genotype; Humans; Italy - epidemiology; Medical sciences; Middle Aged; Molecular genetics; Molecular Sequence Data; Neurology; Polymorphism; Italy; Europe; Molecular genetics; Apolipoprotein E; Alzheimer's disease; Polymorphism; Human; Nervous system diseases; Sporadic; Alzheimer disease; Etiology; Family study; Genetics; Degenerative disease; Apolipoproteins
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/0304-3940(94)90054-X

Recent studies have provided evidence of association of apolipoprotein E (ApoE) ε4 allele and late onset familial and sporadic Alzheimer's disease (AD). Epidemiological studies have established allelic variation at the ApoE locus. We have analyzed the ApoE gene polymorphism in a sample of 446 Italian subjects. Our data confirm a significant association between ε4 allele and sporadic AD. The frequency of ε4 allele in early onset familial AD patients was comparable to control values suggesting that ε4 allele does not represent a risk factor for early onset familial AD (EOFAD). Moreover, we found a not previously reported association between ApoE ε2 allele and sporadic AD and EOFAD.