Prolonged oral sildenafil use-induced Mondor disease: a case report

• Published in: Journal of yeungnam medical science Vol. 39; no. 3; pp. 262 - 265
• Main Authors: Chung, Han Sol, Mun, You Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) Journal of Yeungnam Medical Science 01.07.2022; Yeungnam University College of Medicine, Yeungnam University Institute Medical Science; 영남대학교 의과대학
• Subjects: Case Report; mondor disease; sildenafil citrate; venous thrombosis; 의학일반; Mondor disease; Sildenafil citrate; Venous thrombosis
• ISSN: 2799-8010; 2799-8010
• DOI: 10.12701/jyms.2022.00220

Penile Mondor disease (MD) is a palpable, painful, subcutaneous induration caused by superficial dorsal penile vein thrombosis. We report a case of penile MD that was suspected to be related to prolonged oral sildenafil use. A 46-year-old man visited our emergency department with sustained penile pain and swelling that began 7 hours after sexual intercourse. He had used oral sildenafil intermittently for 11 years and engaged in sexual intercourse the previous night after taking sildenafil. Examination revealed no evidence of intercourse-related trauma to the genital area or an increase in penile skin temperature. However, penile swelling and tenderness over the protruding dorsal penile vein were noted. A color Doppler ultrasound examination was performed immediately, which showed hyperechoic thrombosis in the right superficial dorsal penile vein that was dilated, with soft tissue swelling and no detectable flow signal in the thrombotic lesion. The patient was diagnosed as having penile MD. The patient was treated conservatively. Some reports have indicated the involvement of sildenafil in thrombogenesis. Physicians should be aware that prolonged oral sildenafil use may be associated with penile MD.