ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus

• Published in: Disease markers Vol. 2016; no. 2016; pp. 1 - 6
• Main Authors: Zhao, Hai-lu, Geng, Li-Jun, Chen, Yin-Ling, Wang, Ying-Hui, Huang, Yan-Mei, Wang, Min, Pan, Yan-Hong, Zhang, Xiao-xi
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc
• Subjects: Angiotensin converting enzyme; Biomarkers - metabolism; Blood Glucose - analysis; Cross-Sectional Studies; Development and progression; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - etiology; Female; Follow-Up Studies; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Health aspects; Humans; Hypertension - complications; Hypertension - genetics; Male; Middle Aged; Obesity; Obesity - complications; Obesity - genetics; Overweight - complications; Overweight - genetics; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic - genetics; Prognosis; Risk factors; Thinness - complications; Thinness - genetics; Type 2 diabetes; China
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2016/7420540

Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial. We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. In this study, obesity was defined as a body mass index (BMI) value ≥ 25 kg/m2 and subjects were classified into 4 groups (lean, normal, overweight, and obese). PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism in T2DM patients. Metabolic measurements including blood glucose, lipid profile, and blood pressure were obtained. Frequencies of the ACE genotypes (DD, ID, and II) were not significant among the 4 groups of BMI-defined patients (P=0.679) while ACE II carriers showed higher systolic blood pressure (SBP) and pulse pressure (PP) (all P<0.050). Hyperglycemia, hypertension, and dyslipidemia in these T2DM patients were found to be significantly associated with BMI. In conclusion, the relationship of ACE gene I/D polymorphism with obesity is insignificant in Chinese patients with T2DM. SBP and PP might be higher in the ACE II carriers than in the DD and ID carriers.