Helicobacter pylori Infection among Aborigines (the Orang Asli) in the Northeastern Region of Peninsular Malaysia

Whether the exceptionally low prevalence of Helicobacter pylori (HP) infection reported among Malays is also present among aborigines (the Orang Asli) living in northeastern Peninsular Malaysia is unknown. We studied asymptomatic Orang Asli from settlements situated 210 km from the city of Kota Bhar...

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Published inThe American journal of tropical medicine and hygiene Vol. 83; no. 5; pp. 1119 - 1122
Main Authors AMRY ABDUL RAHIM, YEONG YEH LEE, ABD MAJID, Noorizan, EE CHOO, Keng, SUNDRAMOORTHY MAHENDRA RAJ, DERAKHSHAN, Mohammad H, GRAHAM, David Y
Format Journal Article
LanguageEnglish
Published Deerfield, IL American Society of Tropical Medecine and Hygiene 01.11.2010
The American Society of Tropical Medicine and Hygiene
Subjects
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Cohort Studies
Female
Helicobacter Infections - epidemiology
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Infectious diseases
Logistic Models
Malaysia - epidemiology
Male
Medical sciences
Middle Aged
Odds Ratio
Population Groups
Risk Factors
Serologic Tests
Young Adult
Asia
Malaysia
Spirillaceae
Aboriginal
Bacteria
Tropical medicine
Spirillales
Helicobacter pylori
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Summary:Whether the exceptionally low prevalence of Helicobacter pylori (HP) infection reported among Malays is also present among aborigines (the Orang Asli) living in northeastern Peninsular Malaysia is unknown. We studied asymptomatic Orang Asli from settlements situated 210 km from the city of Kota Bharu. The HP infection status was confirmed by a validated serology test. Nineteen percent of 480 Orang Asli tested positive for HP infection. The prevalence was 40.6% in the birth cohort of the 1940s and declined steadily in later cohorts to under 10% among 12-30 year olds. This may be related to the phases of relocation from the jungles into resettlement camps and ultimately into designated villages near rivers. The low prevalence pattern after the 1970s was probably partly a result of improvement in sanitation and hygiene practice in these villages but other unidentified factors may also be operating.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2010.10-0226