Using electronic patient records to discover disease correlations and stratify patient cohorts
Electronic patient records remain a rather unexplored, but potentially rich data source for discovering correlations between diseases. We describe a general approach for gathering phenotypic descriptions of patients from medical records in a systematic and non-cohort dependent manner. By extracting...
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Published in | PLoS computational biology Vol. 7; no. 8; p. e1002141 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
01.08.2011
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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Summary: | Electronic patient records remain a rather unexplored, but potentially rich data source for discovering correlations between diseases. We describe a general approach for gathering phenotypic descriptions of patients from medical records in a systematic and non-cohort dependent manner. By extracting phenotype information from the free-text in such records we demonstrate that we can extend the information contained in the structured record data, and use it for producing fine-grained patient stratification and disease co-occurrence statistics. The approach uses a dictionary based on the International Classification of Disease ontology and is therefore in principle language independent. As a use case we show how records from a Danish psychiatric hospital lead to the identification of disease correlations, which subsequently can be mapped to systems biology frameworks. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: F. Roque, P. Jensen, S. Bredkjær, L. Jensen, S. Brunak. Performed the experiments: F. Roque, P. Jensen, H. Schmock, M. Andreatta. Analyzed the data: F. Roque, P. Jensen, H. Schmock, M. Dalgaard, M. Andreatta, T. Hansen, K. Søeby, A. Juul, T. Werge, S. Brunak. Wrote the paper: F. Roque, P. Jensen. |
ISSN: | 1553-7358 1553-734X 1553-7358 |
DOI: | 10.1371/journal.pcbi.1002141 |