Prediction of the Structural Motifs of Sandwich Proteins
We investigate the supersecondary structure of a large group of proteins, the so-called sandwich proteins. The analysis of a large number of such proteins has led us to propose a set of rules that can be used to predict the possible arrangements of strands in the two β-sheets forming a given sandwic...
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Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 48; pp. 16780 - 16783 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
National Academy of Sciences
30.11.2004
National Acad Sciences |
Subjects | |
Online Access | Get full text |
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Summary: | We investigate the supersecondary structure of a large group of proteins, the so-called sandwich proteins. The analysis of a large number of such proteins has led us to propose a set of rules that can be used to predict the possible arrangements of strands in the two β-sheets forming a given sandwich structure. These rules imply the existence of certain invariant supersecondary substructures common to all sandwich proteins. Furthermore, they dramatically restrict the number of permissible arrangements. For example, whereas for proteins consisting of three strands in each β-sheet 180 possible strand arrangements exist a priori, our rules imply that only 15 of them are permissible. Five of these predicted arrangements describe all currently known sandwich proteins with six strands. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Abbreviations: JP, jumping pair; EJP, edge JP; IJP, internal JP; NS, neighboring strand(s). Contributed by I. M. Gelfand, October 19, 2004 To whom correspondence should be addressed. E-mail: igelfand@math.rutgers.edu. Author contributions: A.S.F., I.M.G., and A.E.K. designed research, performed research, analyzed data, and wrote the paper. |
ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.0407570101 |