Multifocal Primary Intracerebral Malignant Fibrous Histiocytoma Case Report

• Published in: Neurologia medico-chirurgica Vol. 44; no. 5; pp. 249 - 254
• Main Authors: MITSUHASHI, Takashi, WATANABE, Mitsuya, OHARA, Yukoh, HATASHITA, Shizuo, UENO, Hideo
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 01.05.2004
• Subjects: brain; Brain Neoplasms - diagnosis; Brain Neoplasms - surgery; Female; Histiocytoma, Benign Fibrous - diagnosis; Histiocytoma, Benign Fibrous - surgery; Humans; malignant fibrous histiocytoma; Middle Aged; multifocal primary tumor
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.44.249

A 58-year-old female presented with a unique case of multifocal primary intracerebral malignant fibrous histiocytoma (MFH) manifesting as partial seizure. Neuroimaging showed a mass lesion in the right frontal lobe, which was totally removed. The histological diagnosis was MFH. Follow-up neuroimaging one month after surgery showed another lesion rapidly growing in the left frontal lobe. This lesion was totally removed, and identified as MFH. Her condition gradually worsened. Neuroimaging performed 3 months after first operation revealed bilateral recurrence. She died of respiratory failure 7 months after the initial diagnosis of MFH. Primary intracranial MFH is an extremely rare entity with only 31 cases of solitary tumor previously reported.