Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study

• Published in: British journal of cancer Vol. 104; no. 9; pp. 1482 - 1486
• Main Authors: POGODA, J. M, NICHOLS, P. W, ROSS, R. K, STRAM, D. O, THOMAS, D. C, PRESTON-MARTIN, S
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 26.04.2011
• Subjects: Adult; Aged; Anemia; Biological and medical sciences; Bone marrow; California - epidemiology; Cancer research; Case-Control Studies; Drug dosages; Ethnicity; Female; Hematologic and hematopoietic diseases; Humans; Interviews; Leukemia; Leukemia, Myeloid, Acute - epidemiology; Leukemia, Myeloid, Acute - ethnology; Leukemia, Myeloid, Acute - etiology; Leukemia, Myeloid, Acute - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical Records; Medical research; Medical sciences; Middle Aged; Pathology; Preventive medicine; Radiation; Radiography; Radiography - adverse effects; Retrospective Studies; Risk Assessment; Risk Factors; Short Communication; Surveys and Questionnaires; Tumors; Ultrasonic imaging; California; Los Angeles County California; Los Angeles California; United States > US; Human; Acute myelogenous leukemia; Radiodiagnosis; Exploration; Malignant hemopathy; Case control study; diagnostic imaging; Medicine; Radiography; Ionizing radiation; ionising radiation; Cancerology; acute myeloid leukaemia; case-control study; Adult; Medical imagery; Diagnosis; Bibliographic review; Cancer
• ISSN: 0007-0920; 1532-1827; 1532-1827
• DOI: 10.1038/bjc.2011.114

Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. Subjects were 412 matched case-control pairs. Ten-year subject histories of diagnostic radiography were based on interview and medical records. There was no convincing association between AML risk and ionising radiation exposure from diagnostic imaging procedures, either for AML overall or for any AML subtype. The association between diagnostic radiography and AML risk remains uncertain.