Effectiveness of non-pharmacological traditional Chinese medicine combined with conventional therapy in treating fibromyalgia: a systematic review and meta-analysis

• Published in: Frontiers in neuroscience Vol. 17; p. 1097475
• Main Authors: Cai, Lili, Chen, Zhengquan, Liang, Juping, Song, Yuanyuan, Yu, Hong, Zhu, Jiaye, Wu, Qikai, Zhou, Xuan, Du, Qing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 01.06.2023; Frontiers Media S.A
• Subjects: Acupuncture; Antidepressants; Clinical trials; depression; Drug therapy; Emotions; Fibromyalgia; Holism; Intervention; Meta-analysis; Neuroscience; Pain; Patient education; Quality of life; Rheumatism; Systematic review; Traditional Chinese medicine; traditional Chinese medicine; pain; depression; quality of life; systematic review; fibromyalgia
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2023.1097475

Fibromyalgia is a chronic musculoskeletal disorder characterized by generalized pain, which is also known as "muscular rheumatism" in Chinese medicine. We undertook this systematic review to evaluate the effectiveness of non-pharmacological traditional Chinese medicine (TCM) combined with conventional therapy on pain, health status, depression, and the quality of life of fibromyalgia patients. Studies were retrieved from five electronic databases (PubMed, the Cumulative Index to Nursing and Allied Health, Cochrane Library, Embase, and Web of Science) with publication date up to August 2022. We included randomized controlled trials examining the effects of a combination of non-pharmacological TCM and conventional therapy on pain intensity, health status, depression, and quality of life. Four randomized controlled trials with 384 fibromyalgia patients met the inclusion criteria. Results of the meta-analysis showed that non-pharmacological TCM combined with conventional therapy exerted significant positive effects on alleviating pain at the post-intervention time point than conventional therapy only (visual analog scale WMD = -1.410, < 0.01; pressure pain threshold WMD = 0.830, < 0.001, respectively). Significant differences in pain assessment were also observed between the two groups after a long-term follow-up (12 months) (WMD = -1.040 and WMD = 0.380, all < 0.05). The combination therapy group also showed a greater reduction in fibromyalgia impact questionnaire than the control group after a long-term follow-up (WMD = -6.690, < 0.05). Depression and pain-related quality of life showed no difference between groups (all > 0.05). Non-pharmacological TCM combined with conventional therapy may be more effective in alleviating pain and improving health status than conventional therapy only. However, it remains some concerns over the safety and clinic application. Identifier: CRD42022352991.