Optimal intracellular calcium signaling

In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding). These channels are clustered with a typical cluster size of about 20 channels, generating stochastic calcium puffs. We find that the clusterin...

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Bibliographic Details
Published inPhysical review letters Vol. 88; no. 6; p. 068102
Main Authors Shuai, J W, Jung, P
Format Journal Article
LanguageEnglish
Published United States 11.02.2002
Subjects
Calcium - metabolism
Calcium Channels - metabolism
Calcium Signaling - physiology
Cytosol - metabolism
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - physiology
Inositol 1,4,5-Trisphosphate Receptors
Kinetics
Models, Biological
Receptors, Cytoplasmic and Nuclear - metabolism
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Summary:In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding). These channels are clustered with a typical cluster size of about 20 channels, generating stochastic calcium puffs. We find that the clustering of the release channels in small clusters increases the sensitivity of the calcium response, allowing for coherent calcium responses at signals to which homogeneously distributed channels would not respond.
ISSN:0031-9007
DOI:10.1103/PhysRevLett.88.068102