Target of rapamycin (TOR) in nutrient signaling and growth control

TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of th...

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Published inGenetics (Austin) Vol. 189; no. 4; pp. 1177 - 1201
Main Authors Loewith, Robbie, Hall, Michael N
Format Journal Article
LanguageEnglish
Published United States Genetics Society of America 01.12.2011
Subjects
Cell growth
Genetics
Kinases
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - physiology
Signal transduction
Signal Transduction - physiology
Yeast
YeastBook
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Summary:TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.111.133363