Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts

• Published in: Food chemistry Vol. 141; no. 3; pp. 2501 - 2506
• Main Authors: Costa, Patrícia, Gonçalves, Sandra, Valentão, Patrícia, Andrade, Paula B., Almeida, Carlos, Nogueira, José M.F., Romano, Anabela
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2013; Elsevier
• Subjects: Adult and adolescent clinical studies; Alzheimer’s disease; Animals; Anti-cholinesterases; Antioxidants; Antioxidants - chemistry; Antioxidants - metabolism; Antioxidants - pharmacology; Biological and medical sciences; Cholinesterase Inhibitors - chemistry; Cholinesterase Inhibitors - metabolism; Cholinesterase Inhibitors - pharmacology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Essential oil; Gas Chromatography-Mass Spectrometry; General pharmacology; Lavandula; Lavandula - chemistry; Lavandula - metabolism; Lavandula pedunculata subsp. lusitanica; Lipid Peroxidation - drug effects; Medical sciences; Metabolome; Mice; Monoterpenes - chemistry; Monoterpenes - metabolism; Monoterpenes - pharmacology; Neurology; Oils, Volatile - chemistry; Oils, Volatile - metabolism; Oils, Volatile - pharmacology; Organic mental disorders. Neuropsychology; Pedunculata; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phenolic compounds; Plant Extracts - chemistry; Plant Extracts - metabolism; Plant Extracts - pharmacology; Portugal; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Portugal; BChE; Lavandula pedunculata subsp. lusitanica; AAPH; ACh; ATCI; MDA; HPLC–DAD; AUC; BHT; Antioxidants; Anti-cholinesterases; Aβ; TBA; Essential oil; ORAC; AChE; GC–MS; AD; SDS; DTNB; Alzheimer’s disease; BTCI; TBARS; EDTA; Phenolic compounds; TE; TEAC; Trolox; HD; ABTS; Nervous system diseases; Alzheimer disease; Extract; Antioxidant; Metabolism; Biological activity; Cerebral disorder; Lavandula; lusitanica; Labiatae; Dicotyledones; Angiospermae; Plant origin; Central nervous system disease; Phenols; Lavandula pedunculata subsp; Degenerative disease; Spermatophyta; Anticholinesterase agent; Alzheimer's disease; thiobarbituric acid-reactive substances; acetylthiocholine iodide; 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid; butylated hydroxytoluene; ethylenediaminetetraacetic acid; malondialdehyde; thiobarbituric acid; amyloid beta; gas chromatography–mass spectrometry; hydrodistillation; high-performance liquid chromatography–diode array detection; butyrylthiocholine chloride; 2,2′-azobis(2-methylpropionamidine) dihydrochloride; butyrylcholinesterase; oxygen radical absorbance capacity; Trolox equivalent antioxidant capacity; Trolox equivalents; 2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation; acetylcholinesterase; area under the curve; 5,5′-dithiobis [2-nitrobenzoic acid]; acetylcholine; ABTS(+); sodium dodecylsulphate
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2013.05.055

•We studied the Lavandula pedunculata subsp. lusitanica metabolic profile.•Oxygen-containing monoterpenes were the main compounds in the essential oil.•Hydroxycinnamic acids and flavones are present in the polar extracts.•L. pedunculata metabolites have antioxidant and anti-cholinesterases activities.•Extraction solvent influences the recovery of phenolic compounds and biological activity. We investigated the metabolic profile and biological activities of the essential oil and polar extracts of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco collected in south Portugal. Gas chromatography–mass spectrometry (GC–MS) analysis revealed that oxygen-containing monoterpenes was the principal group of compounds identified in the essential oil. Camphor (40.6%) and fenchone (38.0%) were found as the major constituents. High-performance liquid chromatography with diode array detection (HPLC–DAD) analysis allowed the identification of hydroxycinnamic acids (3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid being the main compound in most of them. The bioactive compounds from L. pedunculata polar extracts were the most efficient free-radical scavengers, Fe2+ chelators and inhibitors of malondialdehyde production, while the essential oil was the most active against acetylcholinesterase. Our results reveal that the subspecies of L. pedunculata studied is a potential source of active metabolites with a positive effect on human health.