Results of up to 9 years of high-temperature- fixed valvular bioprostheses in a young population
Background. Bioprosthetic valve replacement in young patients remains a controversial issue due to a high rate of early calcification. Previous studies in our laboratory have shown that high-temperature fixation of glutaraldehyde preserved bioprosthesis (HTF) mitigates calcification. The first clini...
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Published in | The Annals of thoracic surgery Vol. 71; no. 5; pp. S353 - S355 |
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Main Authors | , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
New York, NY
Elsevier Inc
01.05.2001
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Background. Bioprosthetic valve replacement in young patients remains a controversial issue due to a high rate of early calcification. Previous studies in our laboratory have shown that high-temperature fixation of glutaraldehyde preserved bioprosthesis (HTF) mitigates calcification. The first clinical application of this technique was started in 1991.
Methods. From January 1991 to September 1998, 50 patients in whom anticoagulants were contraindicated underwent single aortic valve replacement (n = 33) or mitral valve replacement (n = 17) using HTF bioprostheses. The age of the patients ranged from 7 months to 35 years (mean 22.7 ± 6.8 years). The mean New York Heart Association status was 2.4. Mean follow-up 4 years ± 1.8 for a total follow-up of 196 patient-years.
Results. There were no operative deaths and but there were two late deaths, one valve related. Structural failure occured in 4 patients (2%/patient-year) requiring a reoperation in 3 patients (1.5%/patient-year). No endocarditis or thromboembolic episodes were observed. At late examination (June 2000), 46 patients (92%) were in New York Heart Association class I or II, with a well functioning valve.
Conclusions. Replacement with HTF bioprostheses in young patients has demonstrated encouraging midterm results with a low incidence of structural failure |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0003-4975 1552-6259 |
DOI: | 10.1016/S0003-4975(01)02558-9 |