No effect of bovine interferon-tau for control of calf diarrhea and immunomodulation in calves

• Published in: Journal of Veterinary Medical Science Vol. 66; no. 9; pp. 1161 - 1164
• Main Authors: Kohara, J. (Hokkaido. Animal Research Center, Shintoku (Japan)), Yayota, C, Yokomizo, Y
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.09.2004
• Subjects: Animals; Animals, Newborn - immunology; Animals, Newborn - metabolism; Animals, Newborn - virology; calf; CALVES; Cattle; Cattle Diseases - diagnosis; Cattle Diseases - drug therapy; diarrhea; Diarrhea - diagnosis; Diarrhea - drug therapy; Diarrhea - veterinary; DIARRHOEA; IMMUNOTHERAPY; INTERFERON; Interferon Type I - immunology; Interferon Type I - therapeutic use; interferon-τ; Lymphocyte Count - veterinary; Pregnancy Proteins - immunology; Pregnancy Proteins - therapeutic use; Time Factors
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.66.1161

Newborn calves received a low dose of bovine interferon-tau (boIFN-tau) orally for 4 weeks and calves that had developed diarrhea received a low dose of boIFN-tau orally for 5 days. No effects of boIFN-tau were seen in the duration of the diarrhea, or in daily weight gain. Calves received a high dose of boIFN-tau. subcutaneously 3 times and they were then stimulated with bovine herpesvirus type 1 vaccine. No adverse effects were observed after the administration of boIFN-tau and lymphocyte subsets from calves did not change after the stimulation. Our results suggest that boIFN-tau does not seem protecting for preventing calves from diarrhea, recovering the health of calves with diarrhea or immunomodulation, although the treatment itself is not toxic.