Drinking and future thinking: acute effects of alcohol on prospective memory and future simulation

• Published in: Psychopharmacologia Vol. 208; no. 2; pp. 301 - 308
• Main Authors: Paraskevaides, Theadora, Morgan, Celia J. A., Leitz, Julie R., Bisby, James A., Rendell, Peter G., Curran, H. Valerie
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2010; Springer; Springer Nature B.V
• Subjects: Alcohol Drinking - adverse effects; Alcohol Drinking - psychology; Alcohol use; Alcoholism - psychology; Alcoholism - rehabilitation; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Central Nervous System Depressants - adverse effects; Cognition - drug effects; Double-Blind Method; Ethanol - adverse effects; Female; Future; Humans; Male; Medical sciences; Memory; Memory - drug effects; Neurosciences; Original Investigation; Pharmacology/Toxicology; Psychiatry; Psychopharmacology; Simulation; Thinking - drug effects; Time Factors; Young Adult; Context; Prospective memory; Episodic future thinking; Alcohol; Future event simulation; Episodic memory; Executive functioning; Alcoholic beverage; Executive function; Acute; Drinking; Anticipation
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-009-1731-0

Background It has recently been shown that acute alcohol globally impairs ‘prospective memory’ (PM)—remembering to do something in the future (Leitz et al. in Psychopharmacology 205:379–387, 2009 ). In healthy, sober individuals, simulating future events at encoding enhances PM performance. Aims We therefore aimed to determine if future event simulation could attenuate the impairing effects of acute alcohol on PM. Methods Using a double-blind independent group design, 32 healthy volunteers were administered a 0.6-g/kg dose of ethanol or matched placebo. PM performance was assessed using a behavioural task, the ‘Virtual Week’, which was adapted to enable future event simulation in both remote and recent contexts. Episodic memory was indexed with a source memory task and planning with the Tower of London task. Results We replicated the finding of Leitz et al. that acute alcohol consumption impairs prospective memory for event-based tasks. Future event simulation significantly improved PM performance on these tasks and eliminated the PM deficit caused by acute alcohol consumption. Conclusions This is the first evidence that future event simulation can overcome alcohol-induced deficits in prospective memory and may have important clinical implications for the rehabilitation of chronic alcohol users.