Interaction of Diphenyltin(IV) Dichloride with Some Selected Bioligands

• Published in: Chemical & pharmaceutical bulletin Vol. 49; no. 3; pp. 253 - 257
• Main Authors: MOHAMED, Mahmoud Mohamed Ahmed, SHOUKRY, Mohamed Mohamed
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.03.2001; Maruzen; Japan Science and Technology Agency
• Subjects: Algorithms; amino acid; Chemical Phenomena; Chemistry; Chemistry, Physical; dicarboxylic acid; diphenyltin(IV) dichloride; DNA constituent; Drug Carriers - chemistry; equilibrium study; Exact sciences and technology; Ge, sn, pb derivatives; Hydrogen-Ion Concentration; Indicators and Reagents; Ligands; Organic chemistry; Organometalloidal and organometallic compounds; Organotin Compounds - chemistry; peptide; Potentiometry; Preparations and properties; Equilibrium constant; Thiol; Organic ligand; Stability constant; Penicillamine; Sulfur containing aminoacid; α-Aminoacid; Tin IV Complexes; Medium effect; pH; Chloro complex; Aminothiol; Tin Organic compounds
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.49.253

The interaction of diphenyltin(IV) with selected bioligands having a variety of model functional groups were investigated using the potentiometric technique. The hydrolysis constants of diphenyltin(IV) cation and the step-wise formation constants of the complexes formed in solution were calculated using the non linear least-squares program MINIQUAD-75. The participation of different ligand functional groups in binding to organotin is discussed. The concentration distribution of the various complex species was evaluated as a function of pH.