Postoperative cognitive dysfunction—current research progress

Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cogni...

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Published inFrontiers in behavioral neuroscience Vol. 18; p. 1328790
Main Authors Zhao, Qi, Wan, Hui, Pan, Hui, Xu, Yiquan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 30.01.2024
Frontiers Media S.A
Subjects
Alzheimer's disease
Anesthesia
Behavioral Neuroscience
Bone surgery
Brain research
Cardiovascular disease
Cognitive ability
Coronary vessels
Embolisms
Epidemiology
Executive function
Heart surgery
Joint replacement surgery
Molecular modelling
Morbidity
Nervous system
Neurodegenerative diseases
Pathogenesis
Patients
POCD
prevention
review
risk factors
Standard deviation
Standard scores
Surgery
Trauma
Vein & artery diseases
pathogenesis
risk factors
POCD
review
prevention
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Summary:Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery. Furthermore, POCD exacerbates the long-term risk of Alzheimer’s disease (AD). As a result, numerous studies have been conducted to investigate the molecular mechanisms underlying POCD and potential preventive strategies. This article provides a review of the research progress on POCD.
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Reviewed by: Pingping Zhao, University of California, Los Angeles, United States; Thaddee Valdelievre, Baylor Scott and White Health, United States
These authors have contributed equally to this work and share first authorship
Edited by: Miou Zhou, Western University of Health Sciences, United States
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2024.1328790