Oral micro-electronic platform for temperature and humidity monitoring

Intraoral theranostics, the integration of diagnostics and therapeutics within the oral cavity, is gaining significant traction. This pioneering approach primarily addresses issues like xerostomia (dry mouth), commonly resulting from cancer treatment, with a specific focus on monitoring temperature...

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Published inScientific reports Vol. 13; no. 1; p. 21277
Main Authors Popović, Željko V, Thiha, Aung, Ibrahim, Fatimah, Petrović, Bojan B, Dahlan, Nuraina Anisa, Milić, Lazar, Kojić, Sanja, Stojanović, Goran M
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 02.12.2023
Nature Publishing Group UK
Nature Portfolio
Subjects
Cancer therapies
Control systems
Head & neck cancer
Humans
Humidity
Microfluidics
Mouth
Oral carcinoma
Oral cavity
Physical Examination
Precision medicine
Teeth
Temperature
Xerostomia
Xerostomia - diagnosis
Xerostomia - therapy
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Summary:Intraoral theranostics, the integration of diagnostics and therapeutics within the oral cavity, is gaining significant traction. This pioneering approach primarily addresses issues like xerostomia (dry mouth), commonly resulting from cancer treatment, with a specific focus on monitoring temperature and humidity. This paper introduces the innovative Intra-Oral Portable Micro-Electronic (IOPM) fluidic theranostic device platform. It leverages conventional dental spoons by incorporating advanced sensors for precise measurements of oral temperature and humidity. Personalization options include a microfluidic chip and a tooth model, enabling targeted delivery of therapeutic agents to optimize treatment outcomes. The electronic control system simplifies the administration of fluid dosages, intelligently adjusted based on real-time oral cavity temperature and humidity readings. Rigorous experimental evaluations validate the platform's precision in delivering fluid volumes at predefined intervals. This platform represents a transformative advancement for individuals contending with oral health challenges such as xerostomia (dry mouth). Furthermore, it has the potential to elevate oral healthcare standards by providing advanced diagnostics and tailored therapeutic solutions, benefiting both patients and dental professionals alike.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-48379-9