Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa : Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive

Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. H...

Full description

Saved in:
Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 93; pp. 62 - 69
Main Authors Hakkou, Zineb, Maciuk, Alexandre, Leblais, Veronique, Bouanani, Nour Elhouda, Mekhfi, Hassane, Bnouham, Mohammed, Aziz, Mohammed, Ziyyat, Abderrahime, Rauf, Abdur, Hadda, Taibi Ben, Shaheen, Usama, Patel, Seema, Fischmeister, Rodolphe, Legssyer, Abdelkhaleq
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.09.2017
Elsevier
Subjects
Animals
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Cardiology and cardiovascular system
Chlorogenic acid
Chlorogenic Acid - pharmacology
Cinnamates - pharmacology
Cynarin
Human health and pathology
Hypertension
Hypertension - drug therapy
Internal Medicine
Inula - chemistry
Inula viscosa
Life Sciences
Medical Education
Medicine, Traditional - methods
Methanol - chemistry
Methanolic extract
NG-Nitroarginine Methyl Ester - pharmacology
Petra/Osiris/Molinspiration (POM) analysis
Pharmaceutical sciences
Pharmacology
Phytochemicals - pharmacology
Phytotherapy - methods
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rats
Rats, Wistar
Vasodilatator
Vasodilator Agents - pharmacology
Hypertension
Petra/Osiris/Molinspiration (POM) analysis
Methanolic extract
Inula viscosa
Cynarin
Chlorogenic acid
Vasodilatator
Online AccessGet full text

Cover

More Information
Summary:Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. However other compounds would certainly be involved in this effect. POM analysis is affirmative in chlorogenic and cynarin acids as potential models for cardiovascular drug design.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.06.015