The clinical and immunomodulatory effects of green soybean extracts

• Published in: Food chemistry Vol. 138; no. 4; pp. 2300 - 2305
• Main Authors: Katayanagi, Yuki, Yasui, Kensuke, Ikemoto, Hiroyuki, Taguchi, Kyoko, Fukutomi, Ryuta, Isemura, Mamoru, Nakayama, Tsutomu, Imai, Shinjiro
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.06.2013; Elsevier
• Subjects: administration & dosage; Adult; Allergic rhinitis; animal experimentation; Animals; APRIL; B-Lymphocytes; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; BAFF; Biological and medical sciences; Cedar pollinosis; chemistry; Cryptomeria japonica; drug effects; drug therapy; Female; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; genetics; Glycine max; Glycine max - chemistry; Glycine max - growth & development; growth & development; Guinea Pigs; hay fever; Humans; IgE; immunoglobulin E; Immunoglobulin E - immunology; Immunologic Factors; Immunologic Factors - administration & dosage; immunology; Mice; Mice, Inbred BALB C; nasal mucosa; Pilot Projects; Plant Extracts; Plant Extracts - administration & dosage; Pollen; Pollen - immunology; Rhinitis, Allergic, Seasonal; Rhinitis, Allergic, Seasonal - drug therapy; Rhinitis, Allergic, Seasonal - genetics; Rhinitis, Allergic, Seasonal - immunology; Seeds; Seeds - chemistry; Seeds - growth & development; soybeans; splenocytes; Th2 cytokines; tumor necrosis factors; WEGS; WEYS; Withdrawal parallel-group study; WEYS; BAFF; TPA; DMSO; IgE; qRT-PCR; ADL; Cedar pollinosis; Glycine max; WEGS; Th2 cytokines; Allergic rhinitis; TDI; Withdrawal parallel-group study; OVA; APRIL; ELISA; Immunoglobulins; Immunomodulation; Extract; Soybean; Grain legume; Leguminosae; Dicotyledones; Angiospermae; Spermatophyta; Green
• ISSN: 0308-8146; 1873-7072; 1873-7072
• DOI: 10.1016/j.foodchem.2012.12.014

► Green soybean extract regulate the production of BAFF and APRIL in mouse spleen cells. ► Green soybean extract suppressed the TDI-induced nasal mucosa secretion. ► The symptom scores for pollinosis were improved by the green soybean extract. The present study was performed to investigate the immune-modulating activities of extracts from green soybean (Glycine max) in a 2,4-toluene diisocyanate (TDI)-inducing guinea pig rhinitis model and a human trial study for allergic rhinitis. Hot water extracts of green soybean were chosen for animal experimentation on the basis of their ability to regulate the production of B cell-activating factor of the TNF family and a proliferation-inducing ligand in mouse spleen cells. Green soybean extracts significantly decreased the levels of ovalubumin (OVA)-specific IgE in mice and significantly suppressed the TDI-induced nasal mucosa secretion. An open-label human pilot study was performed on 16 subjects, using Japanese cedar pollinosis. The symptom scores for Japanese cedar pollinosis were better in the long-term green soybean extracts intake group than in the withdrawal short-term intake group. Green soybean extracts had great potential as an orally active immune modulator for the treatment of various allergic diseases.