The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer

• Published in: World journal of surgical oncology Vol. 13; no. 1; p. 194
• Main Authors: Shibutani, Masatsune, Maeda, Kiyoshi, Nagahara, Hisashi, Ohtani, Hiroshi, Iseki, Yasuhito, Ikeya, Tetsuro, Sugano, Kenji, Hirakawa, Kosei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.06.2015; BioMed Central
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Biomarkers - blood; Cancer patients; Care and treatment; Colectomy; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - mortality; Colorectal Neoplasms - surgery; Development and progression; Female; Humans; Inflammation - diagnosis; Inflammation - etiology; Leukocyte Count; Lymphatic Metastasis; Lymphocytes - pathology; Male; Middle Aged; Neoplasm Staging; Neutrophils - pathology; Postoperative Complications; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/s12957-015-0609-3

Recently, a preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). However, the prognostic significance of a systemic inflammatory response in the early stage after surgery in patients with CRC is unknown. The aim of this retrospective study was to evaluate the prognostic significance of a postoperative systemic inflammatory response in patients with CRC. Two hundred and fifty-four patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. Univariate and multivariate analyses were performed to evaluate the relationship between the prognosis and clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS), which were measured within two weeks before operation and at the first visit after leaving the hospital. The overall survival rates were significantly worse in the high preoperative NLR/preoperative GPS/postoperative NLR group. A multivariate analysis indicated that only preoperative GPS, postoperative NLR, and the number of lymph node metastases were independent prognostic factors for a poor survival. The postoperative NLR is an independent prognostic factor in patients with CRC who underwent potentially curative surgery.