Interindividual variation in epigenomic phenomena in humans

Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between individuals will have an impact on understanding their broader rol...

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Bibliographic Details
Published inMammalian genome Vol. 20; no. 9-10; pp. 604 - 611
Main Authors French, Hugh J, Attenborough, Rosalind, Hardy, Kristine, Shannon, M. Frances, Williams, Rohan B. H
Format Journal Article
LanguageEnglish
Published New York New York : Springer-Verlag 01.10.2009
Springer New York
Springer Nature B.V
Subjects
Animal Genetics and Genomics
Cell Biology
Chromatin
DNA Methylation
Epigenesis, Genetic
Gene expression
Genetic Variation
Genome, Human
Human Genetics
Humans
Life Sciences
Phenotypes
Variation
Interindividual Variation
Histone Modification
Artificial Reproductive Technology
Nucleosome Location
International HapMap Consortium
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Summary:Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between individuals will have an impact on understanding their broader role in determining variation in gene expression and biochemical, physiological, and behavioural phenotypes. In this review we survey recent progress in this area, focusing on data available from humans. We highlight the role of obligatory (sequence-dependent) epigenomic variation as an important mechanism for generating interindividual variation that could impact our understanding of the mechanistic basis of complex trait architecture.
Bibliography:http://dx.doi.org/10.1007/s00335-009-9219-0
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ISSN:0938-8990
1432-1777
DOI:10.1007/s00335-009-9219-0