Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks

We present a novel kind of directional axon guides for brain-on-a-chip applications. Contrarily to previous works, the directionality in our design is created by rerouting axons growing in the unwanted direction back to their original compartment while leaving the other growth direction unaffected....

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Bibliographic Details
Published inLab on a chip Vol. 16; no. 12; pp. 2188 - 2191
Main Authors Renault, Renaud, Durand, Jean-Baptiste, Viovy, Jean-Louis, Villard, Catherine
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2016
Subjects
Asymmetry
Axons
Biotechnology
Buildings
Chips
Compartments
Life Sciences
Neural networks
Neurobiology
Neurons and Cognition
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Summary:We present a novel kind of directional axon guides for brain-on-a-chip applications. Contrarily to previous works, the directionality in our design is created by rerouting axons growing in the unwanted direction back to their original compartment while leaving the other growth direction unaffected. This design yields state-of-the-art levels of directionality without the disadvantages of previously reported technologies.
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ISSN:1473-0197
1473-0189
DOI:10.1039/c6lc00479b