Onchocerca volvulus Glycolytic Enzyme Fructose-1,6-Bisphosphate Aldolase as a Target for a Protective Immune Response in Humans

• Published in: Infection and Immunity Vol. 70; no. 2; pp. 851 - 858
• Main Authors: MCCARTHY, James S, WIESEMAN, Moira, TROPEA, Joe, KASLOW, David, ABRAHAM, David, LUSTIGMAN, Sara, TUAN, Rocky, GUDERIAN, Ronald H, NUTMAN, Thomas B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2002
• Subjects: Amino Acid Sequence; Animals; Antibodies, Helminth - blood; Antigens, Helminth - chemistry; Antigens, Helminth - genetics; Antigens, Helminth - immunology; Antigens, Helminth - metabolism; Bacteriology; Base Sequence; Biological and medical sciences; Blotting, Northern - methods; Cloning, Molecular; Disease Models, Animal; DNA, Helminth; Female; Fructose-Bisphosphate Aldolase - chemistry; Fructose-Bisphosphate Aldolase - genetics; Fructose-Bisphosphate Aldolase - immunology; Fructose-Bisphosphate Aldolase - metabolism; Fundamental and applied biological sciences. Psychology; Fungal and Parasitic Infections; Glycolysis; Humans; Male; Mice; Mice, Inbred BALB C; Microbiology; Models, Molecular; Molecular Sequence Data; Onchocerca volvulus; Onchocerca volvulus - enzymology; Onchocerca volvulus - genetics; Onchocerciasis - blood; Onchocerciasis - immunology; Onchocerciasis - parasitology; Onchocerciasis - prevention & control; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Protein Structure, Quaternary; Sequence Homology, Amino Acid; T-Lymphocytes - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Synthetic - chemistry; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Vaccines, Synthetic - metabolism; Lyases; Glycolytic enzyme; Prevention; Muscle; Recombinant protein; Nematoda; Human; Immune response; Enzyme; Rodentia; Onchocerca volvulus; Vaccine; Aldehyde-lyases; Parasitosis; Helminthiasis; Fructose; Open reading frame; Infection; Carbon-carbon lyases; Vertebrata; Mammalia; Complementary DNA; Immunogenicity; Mouse; Nematode disease; Helmintha; Fructose-bisphosphate aldolase; Nemathelminthia; Filariosis; Invertebrata
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.70.2.851-858.2002

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