Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

• Published in: Nature communications Vol. 14; no. 1; p. 4709
• Main Authors: Wang, Liu-Chun, Chiou, Pei-Yu, Hsu, Ya-Ping, Lee, Chin-Lai, Hung, Chih-Hsuan, Wu, Yi-Hsuan, Wang, Wen-Jyun, Hsieh, Gia-Ling, Chen, Ying-Chi, Chang, Li-Chan, Su, Wen-Pin, Manoharan, Divinah, Liao, Min-Chiao, Thangudu, Suresh, Li, Wei-Peng, Su, Chia-Hao, Tian, Hong-Kang, Yeh, Chen-Sheng
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 05.08.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Absorption; Animals; Cancer; Catalysis; Catalytic Domain; Cell Line, Tumor; Controllability; Free radicals; Hydrogen Peroxide; Hydroxyl radicals; Male; Mice; Nanoparticles; Near infrared radiation; Neoplasms; Oxidation; Pigments; Simulation analysis; Therapy; Water
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-023-40470-z

Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H O  → ‧OH for tumoral therapy. Unfortunately, H O is often taken from the limited endogenous supply of H O in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe -N ≡ C-Fe composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O , H O and ‧OH from H O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.