Population pharmacokinetics of rosuvastatin: implications of renal impairment, race, and dyslipidaemia

• Published in: Current medical research and opinion Vol. 24; no. 9; pp. 2575 - 2585
• Main Authors: Tzeng, Tsang-Bin, Schneck, Dennis W., Birmingham, Bruce K., Mitchell, Patrick D., Zhang, Harry, Martin, Paul D., Kung, Li-Pin
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2008; Taylor & Francis; Informa Healthcare
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Continental Population Groups; Covariates; Dyslipidaemia; Dyslipidemias - drug therapy; Dyslipidemias - metabolism; Fluorobenzenes - pharmacokinetics; Fluorobenzenes - therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Kidney - physiopathology; Middle Aged; Population pharmacokinetics; Pyrimidines - pharmacokinetics; Pyrimidines - therapeutic use; Race; Renal impairment; Rosuvastatin; Rosuvastatin Calcium; Sulfonamides - pharmacokinetics; Sulfonamides - therapeutic use; Tandem Mass Spectrometry
• ISSN: 0300-7995; 1473-4877
• DOI: 10.1185/03007990802312807

ABSTRACT Objectives: To build the structural model of pharmacokinetics for rosuvastatin and evaluate the impact of demographic characteristics including renal function on its pharmacokinetic parameters. Methods: A population pharmacokinetic analysis of rosuvastatin in healthy volunteers, subjects with dyslipidaemia, and renal failure patients was performed using non-linear mixed-effects modelling and a two-compartment pharmacokinetic model with simultaneous first- and zero-order absorption. Demographic covariates, dyslipidaemic state and renal function were evaluated for their impact on pharmacokinetic parameters by step-wise additions or deletions using the likelihood ratio test. Results: Typical pharmacokinetic parameters were estimated for a healthy white male subject. For example, apparent oral clearance (CL/F ) was estimated to be 257 L/h. Age, smoking status, weight, body surface area, and lean body mass had no significant effect on rosuvastatin pharmacokinetics. The model predicted that CL/F for subjects with creatinine clearance (CLCR ) of 30 mL/min (moderate renal impairment) and of 50 mL/min (mild renal impairment) was 17% and 9.7% lower, respectively, relative to subjects with CLCR of 94 mL/min, the data set median value. CL/F was reduced by 71.1% and 43.7% in subjects with dyslipidaemia and in Asian subjects, respectively. Conclusions: Reduction of CL/F of rosuvastatin is not considered clinically significant for patients with mild-to-moderate renal impairment. Rosuvastatin CL/F was reduced in subjects with dyslipidaemia, but it is important to realise that the safety/efficacy profile of rosuvastatin has been well established in this population. However, the potential for increased exposure in Asian subjects should be considered when initiating rosuvastatin treatment or increasing dose in this population.