Concise Review: Multipotent Mesenchymal Stromal Cells in Blood

Peripheral blood‐derived multipotent mesenchymal stromal cells circulate in low number. They share, most although not all, of the surface markers with bone marrow‐derived multipotent mesenchymal stromal cells, possess diverse and complicated gene expression characteristics, and are capable of differ...

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Bibliographic Details
Published inStem cells (Dayton, Ohio) Vol. 25; no. 1; pp. 69 - 77
Main Authors He, Qiling, Wan, Chao, Li, Gang
Format Journal Article
LanguageEnglish
Published Bristol John Wiley & Sons, Ltd 01.01.2007
Subjects
Animals
Cell Differentiation
Colony-Forming Units Assay
Colony‐forming units fibroblastic
Female
Fetal Blood - cytology
Fetal Blood - physiology
Fetal Development
Humans
Immunophenotyping
Mammals
Mesoderm - cytology
Mesoderm - physiology
Multipotent mesenchymal stromal cells Peripheral blood‐derived multipotent mesenchymal stromal cells
Peripheral blood
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - physiology
Pregnancy
Stromal Cells - cytology
Stromal Cells - physiology
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Summary:Peripheral blood‐derived multipotent mesenchymal stromal cells circulate in low number. They share, most although not all, of the surface markers with bone marrow‐derived multipotent mesenchymal stromal cells, possess diverse and complicated gene expression characteristics, and are capable of differentiating along and even beyond mesenchymal lineages. Although their origin and physio‐pathological function are still unclear, their presence in the adult peripheral blood might relate to some interesting but controversial subjects in the field of adult stem cell biology, such as systemic migration of bone marrow‐derived multipotent mesenchymal stromal cells and the existence of common hematopoietic‐mesenchymal precursors. In this review, current studies/knowledge about peripheral blood‐derived multipotent mesenchymal stromal cells is summarized, and the above‐mentioned topics are discussed.
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ISSN:1066-5099
1549-4918
DOI:10.1634/stemcells.2006-0335