Domains in serum albumin responsible for platelet aggregation

The authors show that there might be two domains in serum albumin; one is responsible for binding with platelets (binding site) and the other is for actual aggregation (aggregating site). The former is not affected by the fatty acids but fatty acids are necessary for the latter to function.

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Bibliographic Details
Published inFEBS letters Vol. 134; no. 2; pp. 249 - 252
Main Authors Imada, Teruaki, Saito, Yuji, Inada, Yuji
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 16.11.1981
Subjects
Adenosine Diphosphate - pharmacology
Animals
Binding Sites
Blood Platelets - metabolism
bovine serum albumin
Calcium - pharmacology
Cattle
cell aggregation
Dose-Response Relationship, Drug
fatty acids
Fatty Acids - pharmacology
Platelet Aggregation - drug effects
platelets
Protein Conformation - drug effects
Serum Albumin, Bovine - metabolism
Serum Albumin, Bovine - pharmacology
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Summary:The authors show that there might be two domains in serum albumin; one is responsible for binding with platelets (binding site) and the other is for actual aggregation (aggregating site). The former is not affected by the fatty acids but fatty acids are necessary for the latter to function.
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ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(81)80612-6