Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment

• Published in: Journal of magnetic resonance imaging Vol. 39; no. 1; pp. 1 - 8
• Main Authors: Venkatesh, Sudhakar K., Wang, Gang, Teo, Lynette L.S., Ang, Bertrand W.L.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2014; Wiley Subscription Services, Inc
• Subjects: Adult; age; Asian Continental Ancestry Group; Body Mass Index; Elastic Modulus; Elasticity Imaging Techniques; Female; gender; Healthy Volunteers; Humans; Liver - pathology; liver stiffness measurement; magnetic resonance elastography; Magnetic resonance imaging; Male; Middle Aged; normal healthy subjects; Reference Values; reproducibility; Reproducibility of Results; liver stiffness measurement; gender; magnetic resonance elastography; normal healthy subjects; reproducibility; age
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.24084

Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m2) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4–6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within‐subject coefficient of variation (CV) of stiffness was estimated. Results The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04–2.15 kPa; range 1.68–2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78–0.96) and CV ranged from 2.2%–11.4%. Conclusion The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1–8. © 2013 Wiley Periodicals, Inc.