Clinicopathologic analysis of stage II-III hepatocellular carcinoma showing early massive recurrence after liver resection

• Published in: Journal of gastroenterology and hepatology Vol. 15; no. 10; pp. 1192 - 1198
• Main Authors: Yamanaka, Junichi, Yamanaka, Naoki, Nakasho, Keiji, Tanaka, Tsuneo, Ando, Tatsuya, Yasui, Chiaki, Kuroda, Nobukazu, Takata, Masafumi, Maeda, Shigeto, Matsushita, Kazuyuki, Uematsu, Kunio, Okamoto, Eizo
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.10.2000; Blackwell Science
• Subjects: Aged; alpha-Fetoproteins - analysis; Angiography; Biological and medical sciences; Biomarkers; Biomarkers, Tumor; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Data Interpretation, Statistical; Female; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; Hepatectomy; hepatocellular carcinoma; Humans; Liver - pathology; Liver Neoplasms - diagnosis; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; liver resection; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - pathology; Prognosis; Protein Precursors - analysis; Prothrombin - analysis; recurrence; Time Factors; Tomography, X-Ray Computed; Tumors; Human; Relapse; Treatment; Surgery; Digestive diseases; Hepatic disease; Hepatocellular carcinoma; Complication; Early; Surgical resection; Malignant tumor; Predictive factor
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1046/j.1440-1746.2000.02323.x

Background and Aims: Prognosis after hepatectomy for hepatocellular carcinoma (HCC) has been improved by progress in the evaluation of hepatic functional reserve, surgical techniques and perioperative management. However, even when curative resection is performed at a relatively early stage, a considerable number of patients develop early intrahepatic and/or extrahepatic recurrence postoperatively. This study analyzed the clinicopathologic features of HCC with early recurrence. Methods: We reviewed records of 513 consecutive patients who had undergone liver resection for HCC. There were 48 deaths within a year after surgery from recurrence, including 21 patients with stage II or III HCC (group I). Clinicopathologic parameters of group I patients were compared with those of 188 patients (group II) who developed recurrence following resection of stage II or III HCC and died more than 1 year after surgery. Results: On univariate analysis, age, tumor diameter (Φ), α‐fetoprotein (AFP):Φ and protein induced by vitamin K absence or antagonist II (PIVKA‐II):Φ were significantly greater in group I than in group II. Macroscopic portal vein invasion, microscopic vascular invasion, intrahepatic metastasis, poor differentiation, pleomorphism, sarcomatous change, vascular lake, and angiographic condensed pooling were more frequently observed in group I than group II. Five independent determinants were selected by multivariate analysis: AFP:Φ, histologic pleomorphism, sarcomatous change, vascular lake and angiographic condensed pooling. Conclusions: Highly malignant HCC with extremely poor prognosis exhibits peculiar clinicopathologic characteristics, particularly histologic immaturity, and can be predicted by preoperative indicators such as markedly elevated tumor marker concentrations and condensed pooling on angiography.