Non-invasive assessment of liver fibrosis in chronic viral hepatitis
Background Hyaluronic acid (HA), ASAT to Platelet Ratio Index (APRI), ASAT/ALAT ratio, Fibrosis 4 score (FIB4) and FibroScan were studied as non‐invasive markers of liver fibrosis (F) in chronic viral hepatitis B (CHB) and C (CHC), in an attempt to avoid the complications of liver puncture biopsy, c...
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Published in | European journal of clinical investigation Vol. 45; no. 12; pp. 1243 - 1251 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.12.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Hyaluronic acid (HA), ASAT to Platelet Ratio Index (APRI), ASAT/ALAT ratio, Fibrosis 4 score (FIB4) and FibroScan were studied as non‐invasive markers of liver fibrosis (F) in chronic viral hepatitis B (CHB) and C (CHC), in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of F. The aim of our research was to study whether HA, APRI, ASAT/ALAT ratio, FIB4 and FibroScan are useful non‐invasive markers in predicting severe F in Romanian patients.
Patients and Methods
This was a prospective multicenter transversal and observational study, which included 76 patients with CHB/CHC. The independent effect of studied markers was tested using multiple binary logistic regression.
Results
In patients with CHB and CHC, the APRI cut‐off value for F4 was 0·70 ng/mL (Se = 77%, Sp = 78%), the FIB4 cut‐off value was 2·01 (Se = 77%, Sp = 69%), and the FibroScan cut‐off value was 13·15 (Se = 92%, Sp = 88%). For patients with CHB/CHC, there was a significant linear positive correlation between F and HA (r = 0·42, P = 0·001), FibroScan (r = 0·67, P < 0·001), APRI (r = 0·46, P < 0·001) and FIB4 (r = 0·51, P < 0·001). Considering age, sex and body mass index as possible confounding factors or covariates in multivariable logistic modelling, FibroScan was the unique test that able to significantly highlight the presence of F4 score in CHB/CHC patients (P = 0·009) while FIB4 test seems to have a tendency to statistical significance.
Conclusion
FibroScan, APRI and FIB4 are useful non‐invasive tests for the evaluation of F4 in patients with CHB and CHC. |
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Bibliography: | ark:/67375/WNG-S8GB3T3M-4 ArticleID:ECI12543 European Social Fund Human Resources Development Operational Programme - No. POSDRU/159/1·5/S/138776 istex:289BF7BCC631CA5EC6412D944FCF465928AF022E ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Undefined-2 ObjectType-Feature-2 |
ISSN: | 0014-2972 1365-2362 |
DOI: | 10.1111/eci.12543 |