Two Cases of Pheochromocytoma Diagnosed Histopathologically as Mixed Neuroendocrine-Neural Tumor

• Published in: Internal Medicine Vol. 34; no. 7; pp. 683 - 687
• Main Authors: WATANABE, Toshiya, NOSHIRO, Takao, KUSAKARI, Taku, AKAMA, Hiroyoshi, SHIBUKAWA, Satoru, MIURA, Wakako, ABE, Keishi, KIMURA, Noriko, MIURA, Yukio
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1995; Japanese Society of Internal Medicine
• Subjects: Adrenal Gland Neoplasms - etiology; Adrenal Gland Neoplasms - pathology; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Biological and medical sciences; Endocrinopathies; ganglioneuroblastoma; ganglioneuroma; Humans; Male; Medical sciences; Mixed Tumor, Malignant - pathology; Neuroblastoma - pathology; neurofibromatosis; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pheochromocytoma - etiology; Pheochromocytoma - pathology; Endocrinopathy; Secretory tumor; Case study; Human; Histopathology; Pheochromocytoma; Diagnosis; Neuroendocrine tumor
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.34.683

We treated two rare cases of pheochromocytoma which were histopathologically diagnosed as mixed neuroendocrine-neural tumor (MNNT): a 35-year-old male patient associated with ganglioneuroblastoma and cutaneous neurofibromatosis and a 42-year-old male patient with ganglioneuroma. Both patients showed typical clinical manifestations of pheochromocytoma without any familial traits. Although each of the diseases has its own entity and clinical features, these tumors are all derived from the neural crest tissues. The tumorigenesis of MNNT is still unknown. Here, a brief review of the recent literature on this subject is discussed. (Internal Medicine 34: 683-687, 1995)