Marine Natural Products. XXVII. Distribution of Lanostane-Type Triterpene Oligoglycosides in Ten Kinds of Okinawan Sea Cucumbers

• Published in: Chemical & pharmaceutical bulletin Vol. 39; no. 9; pp. 2282 - 2287
• Main Authors: KOBAYASHI, Motomasa, HORI, Manabu, KAN, Kumiko, YASUZAWA, Tohru, MATSUI, Matsutaro, SUZUKI, Shigeki, KITAGAWA, Isao
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1991; Maruzen; Japan Science and Technology Agency
• Subjects: 24-dehydroechinoside; Analytical, structural and metabolic biochemistry; Biological and medical sciences; bivittoside; echinoside; Fundamental and applied biological sciences. Psychology; holothurin; holotoxin; lanostane-type triterpane oligoglycoside; Other biological molecules; saponin; sea cucumber; stichloroside; Terpenes, steroids. Hormones; Marine environment; Glycoside; Holothuroidea; Invertebrata; Echinodermata; Triterpene
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.39.2282

Triterpene-oligoglycoside constituents in ten sea cucumber species inhabiting Okinawan coral reefs were investigated. Several antifungal oligoglycosides were isolated from six species [stichlorosides A1 (15), A2 (16), B1 (17), B2 (18), C1 (19), and C2 (20) from Thelonota ananas (baika-namako in Japanese) and Stichopus hermanni; 15, 17, and 19 from Thelonota anax; bivittosides C (13) and D (14) from Bohadschia argus (janome-namako); holothurin A (6) from Holothuria edulis (akamishikiri); and 6 and echinoside A (10) from Bohadschia graeffei (kurote-namako)]. Furthermore, several oligoglycosides were isolated in their desulfated forms from four species [6 and 10 from Holothuria axiologa; holothurin B (4), 6, echinoside B (8), and 10 from Holothuria atra (kuro-namako); 6, 10, and 24-dehydroechinoside A (24) from Holothuria scabra (haneji-namako); and 8, 10, 24-dehydroechinoside B (22), and 24 from Actinopyga mauritiana (kuriiro-namako)]. 24-Dehydroechinoside B (22) is a new lanostane-type triterpene oligoglycoside.