Experimental Study on the Effects of Gentamicin Injection on the Guinea-pig: Electrophysiological Studies

The inner ear distortion induced by gentamicin (GM), a type of aminoglycoside antibiotic, was examined in guinea-pigs. Previous studies which investigated the function of the eighth cranial nerve and organ of Corti using cochlear microphonics (CM) and compound action potential (CAP) reported ototoxi...

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Bibliographic Details
Published inActa oto-laryngologica Vol. 118; no. 3; pp. 362 - 368
Main Author SHUICHIROH HOTTA, MITSUAKI TAKAHASHI, TOSHIHIRO ITOH, KOHTAROH YAMAMURA
Format Journal Article
LanguageEnglish
Published Stockholm Informa UK Ltd 1998
Taylor & Francis
Taylor and Francis
Subjects
Action Potentials - drug effects
Animals
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Cochlea - drug effects
Electrophysiology
Ent. Stomatology
Gentamicins - pharmacology
Guinea Pigs
Male
Medical sciences
Pharmacology. Drug treatments
Potassium Channels - drug effects
Regression Analysis
Vestibulocochlear Nerve - drug effects
Gentamicin
Rodentia
Action potential
Concentration
Experimental study
Intramuscular administration
Electrodiagnosis
Vertebrata
Antibiotic
Chemotherapy
Mammalia
Guinea pig
Treatment
Aminoglycoside
Animal
Biological effect
Antibacterial agent
Microphonic potential
Potassium
Summation
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Summary:The inner ear distortion induced by gentamicin (GM), a type of aminoglycoside antibiotic, was examined in guinea-pigs. Previous studies which investigated the function of the eighth cranial nerve and organ of Corti using cochlear microphonics (CM) and compound action potential (CAP) reported ototoxicity following experimental exposure to GM. In this report, the effects of GM on the cochlea and the eighth cranial nerve were investigated systematically by measuring CM, CAP, summating potentials induced by 90 dB (SPL) tone burst, endocochlear potential (EP) and K+
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489850183449