Genetic and epigenetic alterations of colorectal cancer

Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent eviden...

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Bibliographic Details
Published inIntestinal research Vol. 16; no. 3; pp. 327 - 337
Main Author Hong, Sung Noh
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Association for the Study of Intestinal Diseases 01.07.2018
대한장연구학회
Subjects
Colorectal neoplasms
Epigenesis, genetic
Focused Review: Colorectal Cancer
Mutation
내과학
Colorectal neoplasms
Mutation
Epigenesis, genetic
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Summary:Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent evidences demonstrate that there are interactions between these 2 mechanisms. Genetic mutations enable disruption of epigenetic controls while epigenetic modifications can initiate genomic instability and carcinogenesis. This review summarized genetic mutations and epigenetic modifications in colorectal carcinogenesis and molecular classification of CRC subtype based on genetic or epigenetic biomarkers for treatment response and prognosis. Molecular subtypes of CRC will permit the implementation of precision medicine with better outcome of management for CRC.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1598-9100
2288-1956
DOI:10.5217/ir.2018.16.3.327