Variable Region (Vδ) Gene Segment Most Frequently Utilized in Adult Thymocytes is 3′ of the Constant (Cδ) Region

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 85; no. 21; pp. 8161 - 8165
• Main Authors: Iwashima, Makio, Green, Adrienne, Davis, Mark M., Chien, Yueh-hsiu
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.11.1988; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino acids; Animals; Base Sequence; Biological and medical sciences; Complementary DNA; DNA; DNA probes; Exons; Fundamental and applied biological sciences. Psychology; Gene expression; Genes; Genes, Immunoglobulin; Genetic loci; Genomics; Immunoglobulin Constant Regions - genetics; Immunoglobulin Variable Region - genetics; Mice; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Receptors, Antigen, T-Cell - genetics; T lymphocytes; T-Lymphocytes - immunology; Thymocytes; Human; Adult; Immunogenetics; Gene expression; Thymocyte; Variable region
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.85.21.8161

A variable region (Vδ5) of the T-cell receptor (TcR) δ chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3′ of the constant region (Cδ) element. The Vδ5 coding sequence is in a transcriptional orientation opposite the Jδ (joining region) and Cδ coding elements and rearranges by inversion. The Cδ is divided into four exons, three of which encode amino acids of TcR δ polypeptide, and the fourth comprises the entire 3′ untranslated region. In this respect, Cδ resembles Cα rather than Cβ or Cγ.